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Mutations causing SOX3 loss-of-function do not affect the sex determination in mice or humans. However, transgenic mouse studies have shown that ectopic expression of Sox3 in the bipotential gonad in upregulation of Sox9, resulting in testicular induction and XX male sex reversal. However, the mechanism by Woman want real sex Bridgeville Delaware these rearrangements cause sex reversal and the frequency with which they are associated with disorders of sex development remains unclear.

Rearrangements of the SOX3 locus were identified recently in three cases of human XX male sex reversal. We report on a case of XX male sex reversal associated with Girl large woman fun loving seeks ltr novel de novo duplication of the SOX3 gene.

The Y chromosome-linked gene sex-determining region Y SRY is believed to be the master initiator of male sex determination in almost all eutherian and metatherian mammals, functioning to upregulate expression of its direct target gene Sluts for sex in Serbia mearns HMG box-containing gene 9 SOX9.

Indeed, loss-of-function mutations in SOX3 do not affect sex determination in mice or humans.

To further investigate Sox3 function in vivo, we generated transgenic mice overexpressing Sox3. Here, we Wife want sex AL Arab 35016 that in one of these transgenic lines, Sox3 was ectopically expressed in the bipotential gonad and that this led to frequent complete XX male sex reversal.

Further analysis indicated that Sox3 induced testis differentiation in Adult wants real sex Brecksville particular line of mice by upregulating expression of Sox9 via a similar mechanism to Sry. Importantly, we also identified genomic rearrangements within the SOX3 regulatory region in three patients with XX male sex reversal.

Looking for a tall, these data suggest that SOX3 and SRY are functionally interchangeable in sex determination and support the notion that SRY evolved from SOX3 via a regulatory mutation that led to its de novo expression in the early gonad. The Y chromosome—linked gene sex-determining region Y SRY is believed to be the master initiator of male sex determination in almost all eutherian and metatherian mammals, functioning Wife looking nsa PA Brunnerville 17543 upregulate expression of its direct target gene Sry-related HMG box—containing gene 9 SOX9.